T. Saravanan
Assistant Professor
| Ph. D. | Indian Institute of Technology Madras, 2014 |
| Postdoctoral Research | Technical University of Darmstadt, Germany, 2014-2016 |
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University of Groningen, Netherlands, 2016-2020 |
| Assistant Professor | University of Hyderabad, 2020 – Present |
Phone: +91- 40- 23134815, E-mail: tsaravanan@uohyd.ac.in
Research Interests
- Use of enzyme catalysis in the asymmetric synthesis of active pharmaceutical ingredients (APIs)
- Development of (chemo-)enzymatic cascade process for valuable pharmaceuticals
- Photo-Biocatalysis: Enzyme catalysis in combination with light for sustainable synthesis
- Discovery of novel enzymes & exploring it towards new chemical reactions
- Enhancing the enzyme properties by directed evolution and protein engineering techniques
Selected Publications
- Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions. Lieuwe Biewenga†, Thangavelu Saravanan†, Andreas Kunzendorf, Jan- Ytzen van der Meer, Tjaard Pijning, Pieter G. Tepper, Ronald van Merkerk, Simon J. Charnock, Andy-Mark W. H. Thunnissen, and Gerrit J. Poelarends. ACS Catalysis 2019, 9, 1503−1513. [† These authors contributed equally].
- Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives. Mohammad Z. Abidin, Thangavelu Saravanan, Jielin Zhang, Pieter G. Tepper, Erick Strauss, and Gerrit J. Poelarends. Chemistry: A European Journal, 2018, 24, 17434 – 17438.[Hot Paper].
- Donor Promiscuity of a Thermostable Transketolase by Directed Evolution: Efficient Complementation of 1-Deoxy-D-xylulose-5-phosphate Synthase Activity. Thangavelu Saravanan, Sebastian Junker, Michael Kickstein, Sascha Hein, Marie-Kristin Link, Jan Ranglack, Samantha Witt, Marion Lorilliere, Laurence Hecquet and Wolf- Dieter Fessner. Angewandte Chemie International Edition, 2017, 56, 5358–5362.
- Engineering a Thermostable Transketolase for Arylated Substrates. Thangavelu Saravanan, Marie-Luise Reif, Dong Yi, Marion Lorillire, Franck Charmantray, Laurence Hecquet and Wolf-Dieter Fessner. Green Chemistry, 2017, 19, 481–489.
- Utilization of Whole cell Mediated Deracemization in a Chemoenzymatic Synthesis of Enantiomerically Enriched Polycyclic Chromeno[4,3-b] pyrrolidines. Thangavelu Saravanan and Anju Chadha. Organic & Biomolecular Chemistry, 2014, 12, 4682–4690.
