T. Saravanan
Assistant Professor 
Ph. D. Indian Institute of Technology Madras, 2014          
Postdoctoral Research    Technical University of Darmstadt, Germany, 2014-2016   

University of Groningen, Netherlands, 2016-2020
Assistant Professor University of Hyderabad, 2020 – Present
   
Home Page
Phone: +91- 40- 23134815, E-mail: tsaravanan@uohyd.ac.in 
Research Interests 
  • Use of enzyme catalysis in the asymmetric synthesis of active pharmaceutical ingredients (APIs) 
  • Development of (chemo-)enzymatic cascade process for valuable pharmaceuticals 
  • Photo-Biocatalysis: Enzyme catalysis in combination with light for sustainable synthesis 
  • Discovery of novel enzymes & exploring it towards new chemical reactions 
  • Enhancing the enzyme properties by directed evolution and protein engineering techniques
Selected Publications
  • Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions. Lieuwe Biewenga†, Thangavelu Saravanan†, Andreas Kunzendorf, Jan- Ytzen van der Meer, Tjaard Pijning, Pieter G. Tepper, Ronald van Merkerk, Simon J. Charnock, Andy-Mark W. H. Thunnissen, and Gerrit J. Poelarends. ACS Catalysis 2019, 9, 1503−1513. [† These authors contributed equally]. 
  • Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives. Mohammad Z. Abidin, Thangavelu Saravanan, Jielin Zhang, Pieter G. Tepper, Erick Strauss, and Gerrit J. Poelarends. Chemistry: A European Journal, 2018, 24, 17434 – 17438.[Hot Paper].
  • Donor Promiscuity of a Thermostable Transketolase by Directed Evolution: Efficient Complementation of 1-Deoxy-D-xylulose-5-phosphate Synthase Activity. Thangavelu Saravanan, Sebastian Junker, Michael Kickstein, Sascha Hein, Marie-Kristin Link, Jan Ranglack, Samantha Witt, Marion Lorilliere, Laurence Hecquet and Wolf- Dieter Fessner. Angewandte Chemie International Edition, 2017, 56, 5358–5362.
  • Engineering a Thermostable Transketolase for Arylated Substrates. Thangavelu Saravanan, Marie-Luise Reif, Dong Yi, Marion Lorillire, Franck Charmantray, Laurence Hecquet and Wolf-Dieter Fessner. Green Chemistry, 2017, 19, 481–489.
  • Utilization of Whole cell Mediated Deracemization in a Chemoenzymatic Synthesis of Enantiomerically Enriched Polycyclic Chromeno[4,3-b] pyrrolidines. Thangavelu Saravanan and Anju Chadha. Organic & Biomolecular Chemistry, 2014, 12, 4682–4690.