Prof. Lalitha Guruprasad’s group is pursuing research to understand protein sequence to structure and function correlation. This is achieved by computational studies: protein sequence analysis to identify novel repeats and domains, protein three dimensional structure based complete proteome functional analyses, molecular docking, quantitative structure activity relationship studies and molecular dynamics simulations to explain the molecular basis for function. Research emphasis is on the proteins in M. tuberculosis, H. pylori and human kinases. Some of the hypotheses from computational studies for M. tuberculosis proteins are validated experimentally using methods in molecular biology, protein purification, biochemical and biophysical characterization. Purification and characterization of low molecular weight proteins from plant sources.