Lalitha Guruprasad
Professor
Ph. D. Osmania University, 1994
Postdoctoral Research    Birkbeck College, Univ. of London, 1993 - 1996   

University of Cambridge, 1996 - 1997
  CCMB India, 1998 - 2000
Assistant Professor University of Hyderabad, 2000 - 2004
Associate Professor University of Hyderabad, 2004 - 2010
Professor University of Hyderabad, 2010 - Present  
   
Phone: +91- 40- 23134820, E-mail: lalitha.guruprasad@uohyd.ac.in 
Research Interests 
Prof. Lalitha Guruprasad’s group is pursuing research to understand protein sequence to structure and function correlation. This is achieved by computational studies: protein sequence analysis to identify novel repeats and domains, protein three dimensional structure based complete proteome functional analyses, molecular docking, quantitative structure activity relationship studies and molecular dynamics simulations to explain the molecular basis for function. Research emphasis is on the proteins in M. tuberculosis, H. pylori and human kinases. Some of the hypotheses from computational studies for M. tuberculosis proteins are validated experimentally using methods in molecular biology, protein purification, biochemical and biophysical characterization. Purification and characterization of low molecular weight proteins from plant sources. 

Selected Publications
  • In silico 3D structure modeling and inhibitor binding studies of human male germ cell associated kinase, Tanneeru K, Balla AR, Guruprasad L, Journal of Biomolecular Structure & Dynamics, 2015, 33, 1710. 
  • Structure based annotation of Helicobacter pylori strain 26695 proteome. Singh S, Guttula PK, Guruprasad L. PLoS One. 2014, 9, e115020.
  • Purification and characterization of a stable kunitz trypsin inhibitor from Trigonella foenum-graecum (fenugreek) seeds, Rajender Oddepally, Gopi Sriram, Lalitha Guruprasad, Phytochemistry, 2013, 96, 26.
  • 3D-QSAR and molecular docking studies of 2-pyrimidinecarbonitrile derivatives as inhibitors against falcipain-3, Potshangbam AM, Tanneeru K, Reddy BM, Guruprasad L, Bioorganic & Medicinal Chemistry Letters, 2011, 21, 7219.
  • Cell surface proteins in archaeal and bacterial genomes comprising "LVIVD", "RIVW" and "LGxL" tandem sequence repeats are predicted to fold as beta-propeller, Adindla S, Inampudi KK, Guruprasad, International Journal of Biological Macromolecules, 2007, 41, 454.