Debashis Barik
Ph. D. Indian Association for the Cultivation of Science, 2006 
Postdoctoral Research    Virginia Tech, VA, USA, 2007 - 2010
  Memorial Sloan-Kettering Cancer Center, NY, USA, 2010 - 2012  
Assistant Professor

Jawaharlal Nehru University, 2013
University of Hyderabad, 2013 - 2019
Associate Professor
University of Hyderabad, 2020 - 2022
University of Hyderabad, 2023 - Present
Phone: +91- 40- 23134821, E-mail: 
Research Interests 
The ‘finite number effect’ in chemical reactions, known as chemical noise, is the main cause of creating heterogeneity in a population of genetically identical cells. With the help of tools from physical chemistry, statistical physics and nonlinear dynamics, we investigate theoretically and computationally chemical noise propagation in networks of chemical reactions consisting of various types of feedback and feed-forward regulatory motifs. We are developing theoretical/computational methods to analyze the steady state properties of the dynamical systems that regulate cell fate decision making processes in living cells. Our goal is to uncover the topological requirements of chemical reaction networks in producing robust response in the face of chemical noise inside a living cell. A particular interest is to understand the underlying potential energy landscapes of the cellular differentiation pathways in multicellular organisms.
Selected Publications
  • Origin, heterogeneity and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling, S. Das and D Barik, iScience, 26, 106379 (2023)
  • Emergent bistable switches from the incoherent feed-forward signaling of a positive feedback loop, A. Dey and D Barik, ACS Synthetic Biology, 10, 3117, (2021)
  • Potential landscapes, bifurcations and robustness of tristable networks, A. Dey and D Barik, ACS Synthetic Biology, 10, 391, (2021)
  • Dichotomous nature of bistability generated by negative cooperativity in receptor-ligand binding, A. Dey and D Barik, ACS Synthetic Biology, 8, 1294, (2019)
  • Roughness in the periodic potential induces absolute negative mobility in a driven Brownian ratchet, Archana G R and D Barik*, Physical Review E, 106, 044129, (2022)
  • Roughness in the periodic potential enhances transport in a driven inertial ratchet. Archana G R and D Barik*, Physical Review E, 104, 024103 (2021)