Anuj K. Sharma
Professor
| Ph. D. | IIT Kanpur, 2009 |
| Postdoctoral Research | Washington University in St. Louis, USA, 2009-2014 |
|
Assistant Professor (DST-INSPIRE) |
Central University of Rajasthan, 2014-2016 |
|
Assistant Professor |
Central University of Rajasthan, 2016-2022 |
| Associate Professor | Central University of Rajasthan, 2022-2026 |
| Professor | University of Hyderabad, 2026 - Present |
Phone: +91-9929987969, E-mail: anujks@uohyd.ac.in
Research Interests
Keywords: Alzheimer’s disease, Multifunctional chelators, Amyloid aggregation inhibitors, Anticancer metallodrugs
More specifically, my research focuses on coordination chemistry and its applications in medicinal chemistry, particularly for cancer and Alzheimer’s disease. Our group designs targeted ligands to develop metal complexes with therapeutic potential. We have synthesized series of ruthenium and copper complexes that show promising selective cytotoxicity against cancer cells. Elucidating their mechanisms of cell death is a key ongoing effort, pursued through active collaborations with biologists.
We are also developing multifunctional chelators that can sequester metal ions from amyloid-beta peptides while inhibiting their toxic aggregation. Addressing these socially impactful challenges drives our research forward.
More specifically, my research focuses on coordination chemistry and its applications in medicinal chemistry, particularly for cancer and Alzheimer’s disease. Our group designs targeted ligands to develop metal complexes with therapeutic potential. We have synthesized series of ruthenium and copper complexes that show promising selective cytotoxicity against cancer cells. Elucidating their mechanisms of cell death is a key ongoing effort, pursued through active collaborations with biologists.
We are also developing multifunctional chelators that can sequester metal ions from amyloid-beta peptides while inhibiting their toxic aggregation. Addressing these socially impactful challenges drives our research forward.
- Developing multi-target-drug-ligands for ROS control in neurodegenerative disorders
- Designing new strategies for controlling metal-induced abnormalities in biological systems
- Developing special designed Ru and Cu complexes for targeted anticancer applications
- Molecular and electronic structure of metal complexes of non-innocent ligands, and their applications
Selected Publications
- Development of 2-bis(quinolin-2-ylmethylene)hydrazine based half-sandwich ruthenium(II) arene complexes with high cytotoxicity in castration-resistant prostate cancer cell, Khan, T. A.; Yadav, A.; Kumar, V.; Sharma, A. K. Eur. J. Inorg. Chem., 2025, e202400851..
- Evaluation of Anti-Alzheimer’s Potential of Azo-Stilbene-Thioflavin-T derived Multifunctional Molecules: Synthesis, Metal and A Species Binding and Cholinesterase Activity, Rana, M.; Terpstra, K.; Gutierrez, C.; Xu, K.; Arya, H.; Bhatt, T. K.; Mirica, L. M.; Sharma, A. K. Chem. Eur. J., 2024, e202402748.
- Bis-quinoline ruthenium(II) arene complexes with submicromolar cytotoxicity in castration-resistant prostate cancer cells, Khan, T. A.; Bhar, K.; Bhatt, S.; Kumar, V.; Kumari R.; Sharma, A. K. Chem. Commun., 2024, 60, 1579..
- Azo-Stilbene and Pyridine-Amine Hybrid Multifunctional Molecules to Target Metal Mediated Neurotoxicity and Amyloid-β Aggregation in Alzheimer’s disease Rana, M.; Cho, H.J.; Arya, H.; Bhatt, T. K.; Bhar, K.; Mirica, L. M.; Sharma, A. K. Inorg. Chem. 2022, 61, 10294-10309.
- Development, Evaluation and Effect of Anionic Co-ligand on the Biological Activity of Benzothiazole Derived Copper(II) Complexes, Jain, S.; Bhar, K.; Bandyopadhyaya, S.; Singh, V. K.; Mandal, C. C.; Tapryal, S.; Sharma, A. K. J. Inorg. Biochem., 2020, 210, 111174.
