Philosophy of Our Research
DESIGN, SYNTHESIS AND APPLICATIONS OF MOLECULES HAVING THREE PROXIMAL FUNCTIONAL GROUPS
Bond forming and bond cleavage reactions play the most fundamental role in the ocean of organic chemistry and functional groups are the key players in these reactions. Each functional group has distinct properties and reaction profile. Proximity of functional groups in a molecule creates a unique avenue for reactivity pattern. Thus if two functional groups in a molecule are in proximity, such a molecule shows additional or even entirely different properties besides that of individual functional group present. Such uniqueness is not possible if these two functional groups are several atoms or groups apart.
For more information see Chem. Soc. Rev. 2012, 41, 68-78.
OUR VISION:
Since the proximal presence of two functional groups in a molecule provides a highly divergent and different reaction profile, we envisioned that the molecules containing three proximal functional groups (Fig.1) will not only provide a unique reaction domain but also lead to new concepts in organic synthesis. However literature survey clearly reveals that there are no well established methodologies for synthesis of such molecules.
OUR OBJECTIVES:
- To develop simple and facile strategies for synthesis of diverse classes of molecules containing three functional groups in proximity via one-pot atom economical C-C bond forming reaction.
- To understand the chemistry and properties and to explore the applications of such diverse classes of molecules, containing three functional groups in proximity, in organic synthesis.