E-Mail: basavaiahdchem@uohyd.ac.in
     Phone (O) : +91-4023134812
     Mobile: +91-9949093977
     Fax: +91-4023012460
     [b. Valiveru, Tenali (A.P.)]

High School:    ZPH School, Edlapalli, Tenali, A.P. (1966)
PUC:                   VSR College, Tenali, Andhra University (1967)
B.Sc. :		     Andhra Loyola College, Vijayawada, Andhra University (1970)
M. Sc. : 		     Chemistry Department, BHU (1972)
Ph.D. :		     Chemistry Department, BHU (1979-Supervisor, Professor Gurbakhsh Singh)
Post doc.:	     Chemistry Department, Purdue University  (1980-1983)
                             (in the research group of  Professor Herbert C. Brown)

Research Program: The Baylis- Hillman Reaction

The research group of D. Basavaiah at the University of Hyderabad has been working since June 1984 on the Baylis-Hillman reaction with the main objective of developing it into a powerful C-C-bond forming reaction with high synthetic utility. This group has made significant contributions in this direction.

Selected publications:
  1. A simple synthesis of α-methylene-β-hydroxyalkanones
    D. Basavaiah, V. V. L. Gowriswari Tetrahedron Lett. 1986, 27, 2031-2032.

  2. DABCO catalyzed coupling of α-keto esters with acrylonitrile and methyl acrylate
    D. Basavaiah, T. K. Bharathi, V. V. L. Gowriswari Tetrahedron Lett. 1987, 28, 4351-4352.

  3. DABCO catalyzed dimerization of α,β-unsaturated ketones and nitriles
    D. Basavaiah, V. V. L. Gowriswari, T. K. Bharathi Tetrahedron Lett. 1987, 28, 4591-4592.

  4. A simple synthesis of 2-(1-hydroxyalkyl)acrylonitriles
    D. Basavaiah, V. V. L. Gowriswari Synth. Commun. 1987, 17, 587-591.

  5. Chiral acrylates as substrates in Baylis-Hillman reaction
    D. Basavaiah, V. V. L. Gowriswari, P. K. S. Sarma, P. D. Rao Tetrahedron Lett. 1990, 31, 1621-1624.

  6. Applications of Baylis-Hillman coupling products: a remarkable reversal of stereochemistry from esters to nitriles. A simple synthesis of [2E]-2-methylalk-2-en-1-ols and [2Z]-2-methylalk-2-enenitriles
    D. Basavaiah, P. K. S. Sarma J. Chem. Soc., Chem. Commun. 1992, 955-957.

  7. The Johnson-Claisen rearrangement of 3-hydroxy-2-methylenealkanenitriles: stereoselective synthesis of functionalized trisubstituted alkenes
    D. Basavaiah, S. Pandiaraju Tetrahedron Lett. 1995, 36, 757-758.

  8. The Baylis-Hillman reaction: a novel carbon-carbon bond forming reaction
    D. Basavaiah, P. D. Rao, R. S. Hyma Tetrahedron 1996, 52, 8001-8062.

  9. A new protocol for the synthesis of [E]- 3-benzylidenechroman-4-ones: a simple synthesis of the methyl ether of bonducellin
    D. Basavaiah, M.Bakthadoss, S. Pandiaraju Chem. Commun. 1998, 1639-1640.

  10. A facile one-pot conversion of the acetates of the Baylis-Hillman adducts to [E]-α-methylcinnamic acids
    D. Basavaiah, M. Krishnamacharyulu, R. S. Hyma, P. K. S. Sarma, N. Kumaragurubaran J. Org. Chem. 1999, 64, 1197-1200.

  11. Baylis-Hillman chemistry: a novel synthesis of functionalized 1,4-pentadienes
    D. Basavaiah, N. Kumaragurubaran, D. S. Sharada Tetrahedron Lett. 2001, 42, 85-87.

  12. The Baylis-Hillman chemistry in aqueous media: a convenient synthesis of 2-methylenealkanoates and alkanenitriles
    D. Basavaiah, N. Kumaragurubaran Tetrahedron Lett. 2001, 42, 477-479.

  13. Applications of Baylis-Hillman chemistry: enantioselective synthesis of (-)-methyl 3-aryl-2-methylene-3-(prop-2-yn-1-yloxy)propanoates via chiral leaving group strategy
    D. Basavaiah, N. Kumaragurubaran, D. S. Sharada, R. M. Reddy Tetrahedron 2001, 57, 8167-8172.

  14. A novel and facile synthesis of functionalized [4.4.3] and [4.4.4]propellano-bislactones using acetates of the Baylis-Hillman adducts
    D. Basavaiah, T. Satyanarayana Org. Lett. 2001, 3, 3619-3622.

  15. The Baylis-Hillman reaction: one-pot facile synthesis of 2,4-functionalized 1,4-pentadienes
    D. Basavaiah, D. S. Sharada, N. Kumaragurubaran, R. M.Reddy J. Org. Chem. 2002, 67, 7135-7137.

  16. First example of electrophile induced Baylis-Hillman reaction: a novel facile one-pot synthesis of indolizine derivatives
    D. Basavaiah, A. J. Rao Chem. Commun. 2003, 604-605.

  17. Recent advances in the Baylis-Hillman reaction and applications
    D. Basavaiah, A. J. Rao, T. Satyanarayana Chem. Rev. 2003, 103, 811-891.

  18. Steric factors direct Baylis–Hillman and aldol reactions in titanium tetrachloride mediated coupling between α-keto esters and cyclohex-2-enone derivatives
    D. Basavaiah, B. Sreenivasulu, A. J. Rao J. Org. Chem. 2003, 68, 5983-5991.

  19. A novel, tandem construction of C-N and C-C bonds: facile and one-pot transformation of the Baylis-Hillman adducts into 2-benzazepines
    D. Basavaiah, T. Satyanarayana Chem. Commun. 2004, 32-33.

  20. The Baylis-Hillman reaction: a novel source of attraction, opportunities, and challenges in synthetic chemistry
    D. Basavaiah, K. V. Rao, R. J. Reddy Chem. Soc. Rev. 2007, 36, 1581-1588.

  21. Dimethyl sulfide induced [3+2] annulation strategy: an efficient synthesis of functionalized dihydropyrazole derivatives using the Baylis-Hillman bromides
    D. Basavaiah, S. Roy Org. Lett. 2008, 10, 1819-1822.

  22. The Baylis-Hillman bromides as versatile synthons: a facile one-pot synthesis of indolizine and benzofused indolizine frameworks
    D. Basavaiah, B. Devendar, D. V. Lenin, T. Satyanarayana Synlett, 2009, 411-416.

  23. A Facile one-pot transformation of the Baylis-Hillman adducts into unsymmetrical disubstituted maleimide and maleic anhydride frameworks: a facile synthesis of himanimide A
    D. Basavaiah, B. Devendar, K. Aravindu, A. Veerendhar Chem. Eur. J. 2010, 16, 2031-2035.

  24. Toward understanding the scope of Baylis-Hillman reaction: synthesis of 3-(2-hydroxyphenyl)indolin-2-ones and polycyclic fused furans
    D. Basavaiah, S. Roy, U. Das Tetrahedron, 2010, 66, 5612-5622.

  25. Recent contributions from the Baylis-Hillman reaction to organic chemistry
    D. Basavaiah, B. S. Reddy, S. S. Badsara Chem. Rev. 2010, 110, 5447-5674.

  26. The Baylis-Hillman reaction: a novel concept for creativity in chemistry
    D. Basavaiah, G. Veeraraghavaiah Chem. Soc. Rev. 2012, 41, 68-78

  27. Conceptual influence of the Baylis-Hillman reaction on recent trends in organic synthesis
    D. Basavaiah, B. C. Sahu Chimia 2013, 67, 8-16.

  28. Ketones as electrophiles in two component Baylis-Hillman reaction: a facile one-pot synthesis of substituted indolizines
    D.Basavaiah, G.Veeraraghavaiah, S. S. Badsara Org. Biomol. Chem. 2014, 12, 1551-1555.

  29. The acrylamide moiety as an activated alkene component in the intramolecular Baylis-Hillman reaction: a facile synthesis of functionalized α-methylene lactam and spirolactam frameworks
    D. Basavaiah, G. C. Reddy, K. C. Bharadwaj Eur. J. Org. Chem. 2014, 1157-1162.

  30. Less reactive ketones as electrophiles and acrylamides as activated alkenes in intramolecular Baylis- Hillman reaction: facile synthesis of functionalized γ-lactam frameworks
    D. Basavaiah, G. C. Reddy, K. C. Bharadwaj Tetrahedron, 2014, 70, 7991-7995.

  31. Baylis-Hillman reaction: in situ generated isoquinolinium species as excellent electrophiles for coupling with alkyl acrylates and acrylonitrile
    D. Basavaiah, P. Thamizharasi Eur. J. Org. Chem. 2017, 5135-5140.