Title: Regiodivergent Synthesis of Penta-Substituted Pyrroles through a Cascade [3 + 2] Cyclization of C-Acylimines with Activated Alkynes and Aromatic Nucleophiles
| Author(s) | J Vannada, M Sulthan, D Arun, R Dada, Srinivasarao Yaragorla |
|---|---|
| Publication Year | 2020 |
| Journal Name | The Journal of Organic Chemistry 2020, 85, 6697-6708 |
| Publication Link | https://pubs.acs.org/doi/10.1021/acs.joc.0c00712 |
| Short Description | Highly robust one-pot, four-component cascade cyclization reaction of α-keto aldehydes, anilines, activated alkynes, and aromatic nucleophiles is developed to synthesize a diverse range of pharmaceutically important penta-substituted pyrroles. |