Title: Cu(OTf)2/HFIP Catalyzed Regioselective Cycloisomerization of Indole-C3-functionalized Alkynols to Carbazoles

Author(s)Srinivasarao Yaragorla,* T. Khan and S Chakroborty
Publication Year2024
Journal NameOrg. Biomol. Chem., 2024,22, 3622-3629
Publication Linkhttps://pubs.rsc.org/en/content/articlelanding/2024/ob/d4ob00421c
Short DescriptionWe report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles using Cu(OTf)2/HFIP as the excellent promoter system. The reaction proceeds through a one-pot, domino process of spiro cyclization and 1,2-migration followed by aromatization to deliver carbazoles

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