| Author(s) | Srinivasarao Yaragorla,* and Rajeshwari Tangellapally |
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| Publication Year | 2026 |
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| Journal Name | J. Org. Chem. 2026, 91, xxxx |
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| Publication Link | https://pubs.acs.org/doi/10.1021/acs.joc.6c00947 |
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| Short Description | We developed a regiodivergent synthesis of highly dia-stereoselective pyridazines and pyrazoles from DACs and hydrazines under solventless ball-milling with HFIP. This HFIP-promoted mechanochemical approach eliminates the need for metal catalysts, hazardous solvents, inert at-mospheres, or external heating, representing a significant advancement in sustainable heterocycle synthesis. We de-lineate the structural parameters that dictate the regioselec-tivity, providing a clear roadmap for the synthesis of either heterocyclic core. 13C NMR studies helped elucidate the activation of DAC by HFIP |
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