C-H functionalization
Title: C(sp3)_H functionalization of methyl azaarenes: A Calcium-catalyzed facile synthesis of (E)-2-Styryl azaarenes and 2-aryl-1,3-bisazaarenes
| Author(s) | Srinivas Yaragorla, Ravikrishna D and Garima S |
|---|---|
| Publication Year | 2015 |
| Journal Name | Tetrahedron Lett. 2015, 56, 5924-5929 |
| Publication Link | https://www.sciencedirect.com/science/article/pii/S0040403915300794 |
| Short Description | Alkaline earth (Ca2+) catalyzed sp3 C–H functionalization of methyl azaarenes for the synthesis of biologically important (E)-2-styryl azaarenes, 2-aryl-1,3-bisazaarenes and 3,3-bisazaarenyl indolinones has been described. Initially methyl azaarenes react with aryl aldehydes to give β-hydroxy derivatives, which undergo Ca(II) catalyzed thermodynamic elimination to give the styryl azaarenes in a single step |