Chemical synthesis plays an increasingly significant role in the advancement of life sciences. Our research aims to advance this important paradigm. We show interest towards discovering green reactions and catalysts. Our laboratory mainly focuses on the development of organocatalytic sequential one-pot reactions, asymmetric supramolecular catalysis and organocatalysis, development of multi-component and multi-catalysis cascade reactions, and metal-free carbonyls based click chemistry.
We discovered important reactions based on three-component reductive alkylation (TCRA) and push-pull dienamine (PPD) reactions. Our research also focuses on the theoretical aspects of organocatalysis in finding out the suitable organocatalyst for stereoselective reactions using computational resources which helps in achieving better synthetic methodologies. We also actively engage for the total synthesis of natural products through our lab developed three-component reductive alkylation (TCRA) reactions with minimum synthetic steps.
Our contributions through original developed reactions were used by organic, medicinal, material chemists and those reactions became well-known organic reactions such as
1) Ramachary Reductive Coupling Reaction,
2) Ramachary-Bressy-Wang Cycloaddition,
3) Ramachary Aminoenyne-catalysis,
4) Ramachary Base Induced Ring Opening (BIRO) Reaction,
5) Ramachary Azide-Carbonyl [3+2]-Cycloaddition.
We also focus on the theoretical aspects of organocatalysis and find out the suitable organocatalyst for stereoselective reactions using computational resources. The out come of our research helps to come with better catalysts and synthetic methodologies. Here we describe the first observation of electrostatic and dipole-dipole interactions in proline-catalyzed asymmetric desymmetrization of pro-chiral ketones with nitrosobenzene.
First time we have undertaken challenging research program by looking at the trapping or stabilization of king size pre- or post-transition states of asymmetric reactions through designing new tool "asymmetric supramolecular catalysis". Utilization and characterization of large-size supramolecular rings in the pre-transition state (pre-TS) of enol- or enamine-based Michael reactions for high asymmetric induction was described in our recent work. For example, enantiomerically pure druglike hexahydroxanthenes and spirodihydrocoumarins with three contiguous stereocenters were synthesized through supramolecular catalysis from simple precursors under mild conditions.
