Publication Details:
Title: Sulfoximine-Directed Ruthenium-Catalyzed ortho-C–H Alkenylation of (Hetero)Arenes: Synthesis of EP3 Receptor Antagonist Analogue
| Author(s) | M Ramu Yadav, Raja K Rit, Majji Shankar, Akhila K Sahoo : J. Org. Chem. 2014, 79, 13, 6123-6134 |
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| Journal Name | The Journal of Organic Chemistry |
| journal image URL | http://chemistry.uohyd.ac.in/~aks/wp-content/uploads/ramu_joc_anta.png |
More Details:
The reusable sulfoximine directing-group-assisted Ru(II)-catalyzed chemo- and regioselective ortho-C–H alkenylation of arenes and heteroarenes with acrylates and α,β-unsaturated ketones/vinyl sulfone is shown. The N-aroyl sulfoximine undergoes annulation with diphenylacetylene, delivering isoquinolinones and methyl phenyl sulfoxide. The present protocol is successfully employed for the synthesis of the EP3 receptor antagonist analogue.