Publication Details:
Title: Sulfoximine-Assisted Unsymmetrical Two fold C–H Functionalization of Arenes
| Author(s) | Koushik Ghosh, Arghadip Ghosh, Kallol Mukherjee and Akhila K. Sahoo* : J. Org. Chem. 2020, 85, 8618–8626 |
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| Journal Name | Journal of Organic Chemistry |
| Link to | https://pubs.acs.org/doi/10.1021/acs.joc.0c01010 |
| journal image URL | http://chemistry.uohyd.ac.in/~aks/wp-content/uploads/sirjoc.png |
More Details:
An unprecedented ruthenium (Ru)-catalyzed twofold unsymmetrical annulation of 3-O/N-allyl benzoic acid derivatives with isocyanates for the construction of dihydro-furan/indole-fused phthalimide scaffolds is discussed. This double-unsymmetrical functionalization of both o,o’-C–H bonds of arene moiety is explicitly viable under the influence of methylphenyl sulfoximine directing group constructing three different [C–C/C–C(O)/N–C(O)] bonds under a single catalytic system. A broad scope with all six-carbon-substituted arene motifs, control experiments, and gram-scale synthesis make the synthetic model viable and significant.
https://pubs.acs.org/doi/10.1021/acs.joc.0c01010