Publication Details:
Title: Ruthenium-Catalyzed ortho-C–H Mono- and Di-imidation of Arenes with N-Tosyloxyphthalimide
| Author(s) | M Ramu Yadav, Raja K Rit, Majji Shankar, Akhila K Sahoo: Org. Lett. 2015, 17, 8, 1886-1889 |
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| Journal Name | Organic Letters |
| journal image URL | http://chemistry.uohyd.ac.in/~aks/wp-content/uploads/majjiorglettnew.png |
More Details:
The Ru(II)-catalyzed imidation of the o-C–H bond in arenes with N-tosyloxyphthalimide is realized with the assistance of a methyl phenylsulfoximine (MPS) directing group. This method is applicable to access the hitherto difficult o-C–H di-imidation products. The sequential C–N and C–C bond formation of o-C–H arenes creates peripherally decorated benzoic acid derivatives. The readily removable MPS-DG and easily modifiable phthaloyl moiety make this strategy synthetically viable for constructing highly functionalized C–N bearing arenes and heteroarenes.