Publication Details:
Title: Ruthenium-Catalyzed Intramolecular Hydroarylation of Arenes and Mechanistic Study: Synthesis of Dihydrobenzofurans, Indolines, and Chromans
| Author(s) | Raja K Rit, Koushik Ghosh, Rajib Mandal, Akhila K Sahoo : J. Org. Chem., 2016, 81, 8552-8560 |
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| Journal Name | The Journal of Organic Chemistry |
| journal image URL | http://chemistry.uohyd.ac.in/~aks/wp-content/uploads/rajaorglett.png |
More Details:
A ruthenium-catalyzed, amide-directed intramolecular hydroarylation of alkene-tethered benzamide derivatives is discussed. This method proficiently constructs dihydrobenzofuran, indoline, and chroman skeletons of biological significance in good to excellent yields; the overall process is atom-economical and step-efficient. The reaction exhibits broad scope, tolerating common functional groups, labile protecting units, and heteroaryl motifs. The use of a catalytic amount of base suffices the need. Deuterium scrambling and kinetic studies offer valuable facts for understanding the reaction mechanism.