Publication Details:
Title: Pd(II)-Catalyzed ortho-C–H Oxidation of Arylacetic Acid Derivatives: Synthesis of Benzofuranones
| Author(s) | Raja K Rit, M Ramu Yadav, Akhila K Sahoo : Org. Lett. 2014, 16, 3, 968-971 |
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| Journal Name | Organic Letters |
| journal image URL | http://chemistry.uohyd.ac.in/~aks/wp-content/uploads/majjiorglettnew.png |
More Details:
Pd(II)-catalyzed ortho-C–H acetoxylation of arylacetic acid derivatives is demonstrated with the aid of a novel S-methyl-S-2-pyridylsulfoximine (MPyS) directing group (DG). The α-mono- and α-unsubstituted arylacetic acid derivatives were readily employed in the ortho-C–H acetoxylations. The oxidation products are hydrolyzed, and the MPyS-DG is easily recovered, providing ready access to o-hydroxyarylacetic acids. 3-Mono- and 3-unsubstituted benzofuranones are synthesized from o-hydroxyarylacetic acids.
https://pubs.acs.org/doi/abs/10.1021/ol403699d?prevSearch=r%2Bk%2Brit&searchHistoryKey=