Publication Details:
Title: Biaryl synthesis using highly stablearyl [2-(hydroxymethyl) phenyl] dimethylsilanes and aryl iodides under fluoride-free conditions
| Author(s) | Yoshiaki Nakao, Akhila Sahoo, Akira Yada, Jinshui Chen, Tamejiro Hiyama : Science and Technology of Advanced Materials |
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| Journal Name | Science and Technology of Advanced Materials |
More Details:
Readily accessible and highly stable aryl[2-(hydroxymethyl)phenyl]dimethylsilanes cross-couple with various aryl iodides under mild reaction conditions employing K2CO3 as a base at 50 1C. Use of CuI as a co-catalyst is essential for the success of the present coupling reaction, which tolerates a diverse range of functional groups to afforda wide variety of biaryl products. Intramolecular coordination of a proximal hydroxyl group is considered to efficiently form pentacoordinated silicates having a transferable aryl group at an axial position and facilitate transmetalation from silicon to copper and then to palladium.