Publication Details:
Title: Alkenyl-and aryl [2-(hydroxymethyl) phenyl] dimethylsilanes: an entry to tetraorganosilicon reagents for the silicon-based cross-coupling reaction
| Author(s) | Yoshiaki Nakao, Hidekazu Imanaka, Akhila K Sahoo, Akira Yada, Tamejiro Hiyama : Journal of the American Chemical Society, 2005, 127, 19, 6952-6953 |
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| Journal Name | Journal of the American Chemical Society |
More Details:
Alkenyl- and aryl[2-(hydroxymethyl)phenyl]dimethylsilanes, highly stable tetraorganosilicon reagents, are found to react with aryl and alkenyl iodides in the presence of a palladium catalyst and K2CO3 as a base, significantly milder conditions compared with those ever reported for the silicon-based cross-coupling reactions. The reaction tolerates a wide range of functional groups, including silyl protectors, and allows a gram-scale synthesis to recover and reuse the silicon residue.