Publication Details:

Title: Ag (I)-Catalyzed Cycloisomerization and Cyclization of Ketene Aminals: Construction of Azepine and 1, 2-Dihydropyridine Derivatives

Author(s)	Sanatan Nayak, B Prabagar, Nayan Ghosh, Rajendra K Mallick, Akhila K Sahoo : Synthesis, 2017, 49, 4261-4271 (Invited Article)
Journal Name	Synthesis
journal image URL	http://chemistry.uohyd.ac.in/~aks/wp-content/uploads/nayaksyncover.png

More Details:

Silver-catalyzed cyclization and cycloisomerization of ketene N,N-acetals at room temperature has been developed to access a variety of highly substituted cyclobutene-fused azepine and 1,2-dihydropyridine derivatives. This cost-effective method is reliably implemented for the gram-scale synthesis of azepine and dihydropyridine derivatives. The iodo group in the periphery of the dihydropyridine motif can be functionalized with both Suzuki and Sonogashira reactions.

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588841