Publication Details:
Title: Transformable Sulfoximine Assisted One-Pot Double Annulation of Vinylic C–H Bonds with Unactivated Alkynes
| Author(s) | Majji Shankar, Tirumaleswararao Guntreddi, E Ramesh, Akhila K Sahoo : Org. Lett., 2017, 19, 5665–5668. |
|---|---|
| Journal Name | Organic Letters |
| journal image URL | http://chemistry.uohyd.ac.in/~aks/wp-content/uploads/majjiorglettnew.png |
More Details:
The methylphenyl sulfoximine (MPS) directing group (DG) successfully promotes the one-pot double annulation of acrylic acids with alkynes under Ru catalysis, which is unprecedented. Diverse arrays of pyrido-fused-isoquinolinone skeletons are fabricated from acrylamides, creating two C–C and two C–N bonds in a single operation. The unsymmetrical annulation with two distinct alkynes is presented. The recovery of methylphenyl sulfoxide, a precursor of MPS, validates the synthetic adaptability of transformable-DG (TfDG) in C–H activation.