PUBLICATIONS

26) Evaluating Multienzyme Cascade Routes for Pharmaceutically Relevant Molecules
Karishma Naik, Sangoji Dheeraj, Kodru Jeevani, Thangavelu Saravanan*
Eur. J. Org.Chem., 2024, e202301236 DOI

25) Microbial alcohol dehydrogenases: recent developments and applications in asymmetric synthesis
Anju Chadha,* Santosh Kumar Padhi,* Selvaraj Stella,* Sowmyalakshmi Venkataraman* and Thangavelu Saravanan*
Org. Biomol. Chem., 2024,22, 228 − 251 DOI

24) Visible Light Driven Metal-Free Photoredox Catalyzed α-benzylation and α-oxygenation of N-substituted Tetrahydroisoquinolines: Applications to Synthesis of Natural Products
Selvaraj Elavarasan, Jeyaraj Preety, Ramanjulu Abinaya, Dr. Thangavelu Saravanan, Prof. Kalpattu Kuppusamy Balasubramanian, Dr. Nutalapati Venkatramaiah, Dr. Baburaj Baskar*
Chem. Asian J., 2022, e202200878 DOI

23) Chemo- and Enantioselective Photoenzymatic Ketone Reductions Using a Promiscuous Flavin-dependent Nitroreductase
Alejandro Prats Luján, Mohammad Faizan Bhat, Thangavelu Saravanan,* Gerrit J. Poelarends*
ChemCatChem, 2022, e202200043 DOI

22) Biocatalytic Asymmetric Cyclopropanations via Enzyme-Bound Iminium Ion Intermediates
Andreas Kunzendorf, Guangcai Xu, Dr. Mohammad Saifuddin, Dr. Thangavelu Saravanan, Prof.Dr. Gerrit J. Poelarends*
Angew. Chem. Int. Ed., 2021, 60, 24059 − 24063 DOI

21) Biocatalytic enantioselective hydroaminations enabling synthesis of N-arylalkyl-substituted L-aspartic acids
Mohammad Z. Abidin, Thangavelu Saravanan,* Laura Bothof, Pieter G. Tepper, Andy-Mark W. H. Thunnissen and Gerrit J. Poelarends*.
Org. Biomol. Chem., 2021, 19, 6407 – 6411 DOI

20) The broad amine scope of pantothenate synthetase enables the synthesis of pharmaceutically relevant amides
Mohammad Z. Abidin, Thangavelu Saravanan,* Erick Strauss, and Gerrit J. Poelarends*
Org. Biomol. Chem., 2021, 19, 4515 – 4519 DOI

19) Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds
Jielin Zhang, Mohammad Z. Abidin, Thangavelu Saravanan, and Gerrit J. Poelarends*
ChemBioChem, 2020, 21, 2733 − 2742 DOI

18) Enantiocomplementary Epoxidation Reactions Catalyzed by an Engineered Cofactor-Independent Non-natural Peroxygenase
Guangcai Xu, Michele Crotti, Thangavelu Saravanan, Kim M. Kataja, and Gerrit J. Poelarends*
Angew. Chem. Int. Ed., 2020, 59, 1 – 6. DOI

17) Enantioselective Aldol Addition of Acetaldehyde to Aromatic Aldehydes Catalyzed by Proline-Based Carboligases
Mohammad Saifuddin, Chao Guo, Lieuwe Biewenga,Thangavelu Saravanan, Simon J. Charnock, and Gerrit J. Poelarends*
ACS Catal., 2020, 10, 2522 − 2527. DOI

16) Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners
Jielin Zhang, Eleonora Grandi, Haigen Fu, Thangavelu Saravanan, Laura Bothof, Pieter G. Tepper, Andy‐Mark W. H. Thunnissen, Gerrit J. Poelarends*
Angew. Chem. Int. Ed., 2019, 131, 2 – 9. DOI

15) Biocatalytic Asymmetric Michael Additions of Nitromethane to α,β-Unsaturated Aldehydes via Enzyme-bound Iminium Ion Intermediates
Chao Guo, Mohammad Saifuddin, Thangavelu Saravanan, Masih Sharifi, and Gerrit J. Poelarends*
ACS Catal., 2019, 9, 4369 − 4373. DOI

14) Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions
Lieuwe Biewenga †, Thangavelu Saravanan †, Andreas Kunzendorf, Jan-Ytzen van der Meer, Tjaard Pijning, Pieter G. Tepper, Ronald van Merkerk, Simon J. Charnock, Andy-Mark W. H. Thunnissen, and Gerrit J. Poelarends*
ACS Catal., 2019, 9, 1503 − 1513. [ †These authors contributed equally ] DOI

13) Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives
Mohammad Z. Abidin, Thangavelu Saravanan, Jielin Zhang, Pieter G. Tepper, Erick Strauss, and Gerrit J. Poelarends*
Chem. Eur. J., 2018, 24, 17434 – 17438. DOI

12) Donor Promiscuity of a Thermostable Transketolase by Directed Evolution: Efficient Complementation of 1-Deoxy-D-xylulose-5-phosphate Synthase Activity
Thangavelu Saravanan, Sebastian Junker, Michael Kickstein, Sascha Hein, Marie-Kristin Link, Jan Ranglack, Samantha Witt, Marion Lorilliere, Laurence Hecquet and Wolf-Dieter Fessner*
Angew. Chem. Int. Ed., 2017, 56, 5358 – 5362. DOI

11) Engineering a Thermostable Transketolase for Arylated Substrates
Thangavelu Saravanan, Marie-Luise Reif, Dong Yi, Marion Lorillire, Franck Charmantray, Laurence Hecquet and Wolf-Dieter Fessner*
Green Chem., 2017, 19, 481 – 489. DOI

10) Second-Generation Engineering of a Thermostable Transketolase (TKGst) for Aliphatic Aldehyde Acceptors with either Improved or Reversed Stereoselectivity
Chaoqiang Zhou, Thangavelu Saravanan, Marion Lorillire, Dongzhi Wei, Franck Charmantray, Laurence Hecquet, Wolf-Dieter Fessner, and Dong Yi*
ChemBioChem, 2017, 18, 455 – 459. DOI

9) One-Pot, Two-Step Cascade Synthesis of Naturally Rare L-erythro (3S,4S) ketoses by Coupling a Thermostable Transaminase and Transketolase
Marion Lorillière,  Maxime De Sousa,  Felipe Bruna  Egon Heuson,  Thierry Gefflaut,  Véronique de Berardinis, Thangavelu Saravanan, Dong Yi,  Wolf-Dieter Fessner,  Franck Charmantray,* and Laurence Hecquet*
Green Chem., 2017, 19,425 – 435. DOI

8) Engineering a Thermostable Transketolase for Unnatural Conversion of (2S)-Hydroxyaldehydes
Abdoul Zabar, Marion Lorillire, Dong Yi, Thangavelu Saravanan, Titu Devamani, Lionel Nauton, Franck Charmantray, Virgil Halaine, Wolf-Dieter Fessner,* and Laurence Hecquet*
Adv. Syn. Cat., 2015, 357, 1715 – 1720. DOI

7) A Thermostable Transketolase Evolved for Aliphatic Aldehyde Acceptors
Dong Yi, Thangavelu Saravanan, Titu Devamani, Franck Charmantray, Laurence Hecquet, and Wolf-Dieter Fessner*
Chem. Commun., 2015, 51, 480 – 483. DOI

6) Chemoenzymatic Synthesis of an Enantiomerically Enriched Bicyclic Carbocycle Using Candida parapsilosis ATCC 7330 Mediated Enantioselective Hydrolysis
Thangavelu Saravanan, Anju Chadha,* Tarur Konikkaledom Dinesh, Namasivayam Palani,* and Sengottuvelan Balasubramanian*
Int. J. Org. Chem., 2015, 5, 271 – 281. DOI

5) Utilization of Whole cell Mediated Deracemization in a Chemoenzymatic Synthesis of Enantiomerically Enriched Polycyclic Chromeno[4,3-b] pyrrolidines
Thangavelu Saravanan, and Anju Chadha*
Org. Biomol. Chem., 2014, 12, 4682 – 4690. DOI

4) Palladium-Catalyzed Allylic Alkylation of Allyl Dienol Carbonates: Reactivity, Regioselectivity, Enantioselectivity and Synthetic Applications
Stellios Arseniyadis,* Jérémy Fournier, Thangavelu Saravanan, Oscar Lozano, Sébastien Prevost, Alexis Archambeau, Candice Menozzi, and Janine Cossy*
Synlett, 2013, 24, 2350 – 2364. DOI

3) Stereochemical Preference in Candida parapsilosis ATCC 7330 mediated Deracemization: (E) vs. (Z)-Alkyl-2-hydroxy-4-arylbut-3-enoate
Thangavelu Saravanan,Selvakumar Rajendran, Mukesh Doble, and Anju Chadha*
Tetrahedron: Asymmetry, 2012, 23, 1360 – 1368. DOI

2) Chemoselective Reduction and Transesterification of α-Keto Propargylic Esters mediated by NaBH4/CeCl3.7H2O.
Thangavelu Saravanan, and Anju Chadha*
Syn. Comm., 2011, 41, 2350 – 2358. DOI

1) Biocatalytic Deracemization of Alkyl-2-hydroxy-4-arylbut-3-ynoates using Whole cells of Candida parapsilosis ATCC 7330
Thangavelu Saravanan, and Anju Chadha*
Tetrahedron: Asymmetry, 2010, 21, 2973 – 2980. DOI