About Our Work
The PRS Research Lab is dedicated to advancing the frontiers of organic chemistry through innovative methodologies in sugar and amino acid synthesis. Our mission is to develop novel synthetic routes to complex molecules with significant biological and medicinal relevance, aiming to impact areas such as vaccine development and drug discovery.
We envision a future where our fundamental research contributes to the development of life-saving therapeutics and inspires the next generation of scientific leaders in chemical synthesis and chemical biology.
We have been working on developing novel synthetic methods in carbohydrate chemistry and have made significant contributions to this emerging area. An interesting glycosylation reaction using 1,2-cyclopropanecarboxylated sugars as glycosyl donors to produce 2-C-branched oligo-glyco-amino acids (OGAAs) was introduced for the first time in the field of carbohydrate research. These sugars were coined by us as hybrid sugars.
We recently developed stereoselective methodologies for the synthesis of C-spiro-glycosides, a class of spiro-sugars, and sugar-fused bicycles which are present in a number of bioactive natural products and pharmaceuticals already in the market. In addition, synthetic methods for bioactive natural products from commercially inexpensive sugar-based precursors were developed. New and convenient methodologies were also introduced for the synthesis of carbon-branched C-glycosides and imino-sugar analogues. Currently, we are focusing on the development of glyco-antigens as vaccine candidates for bacterial and viral diseases.
Prof. Perali Ramu Sridhar
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Novel Synthetic Methodologies
We focus on developing efficient and stereoselective new reactions for the construction of complex molecular architectures.
Sugar & Amino Acid Chemistry
Our lab specializes in the intricate synthesis of modified sugars and amino acids, exploring their unique reactivities.
Total Synthesis
We design and execute the total synthesis of complex, biologically active natural products, often using carbohydrates as versatile starting materials.
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Latest News
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05JUN 2025
New Paper Published in JOC!
Our latest research on "Enantiospecific Synthesis of Tetrahydroindolizines from Spiro-cyclopropanecarboxylated Sugars" has been published. Congrats to MV Kamala Lakshmi and Intzar Ali and the team!
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20MAY 2025
Dr. Praveen Successfully Defends Ph.D. Thesis!
A huge congratulations to Dr. Praveen for a brilliant defense of his doctoral research on " The Total Synthesis of Acetogenins and Marine Natural Products from Carbohydrates."
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Join Our Lab
Are you passionate about organic synthesis. The PRS Research Lab offers a collaborative environment for cutting-edge research. We are always looking for prospective Ph.D. students and postdoctoral researchers.
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