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Synthesis of Carbo and Heterocycles and Natural Product analogues We are involved in the synthesis of molecular scaffolds using three different 6-carbon building blocks A, B and C. These compounds have different functionalities at different carbons. We employ these buiding blocks to make different carbo and heterocyclic compounds which will have biological relevance. |
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Synthesis of carbohydrates (oligosaccharides) and glycoconjugates
In this project we pursue chemical synthesis of chitooligosaccharides and related probes having specific acetylated pattern. These compounds will be employed in understanding the structure/function relationships in collaboration with Prof. Moerschbacher’s group in the University of Muenster, Germany. |
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Development of gold catalyzed organic transformations
We develop strategies and methods to make molecules which have biological or material relevance. In this regard, our group has been involving in the development of transition metal catalyzed reactions. Different gold-catalyzed reactions have been developed for the synthesis of biologically relevant molecules such as bicyclic acetals whose skeleton is present in macrolides derived from marine sources and 1-arylnaphthalenes which is the core structure of certain plant derived lignans. Some of the 1-arylnaphthalene derivatives have been found to show antibacterial activity. A small library of these compounds is being synthesized to understand the structure-activity relationship. |
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Synthetic applications of Acetals under transition metal and Brønsted acid catalysis
Use of acetals for synthetic applications other than protecting group for carbonyl function is less explored. Synthetic utilities of in situ generated acetals under transition metal and Brønsted acid catalysis is being explored. Several interesting synthetic applications of this system have been established so far. |
